Successfully Reducing Asthma Attacks and Improving Asthma Control in Black and Latinx Adults with Moderate-Severe Asthma (PREPARE)
What are the results of the study?
The PARTICS group (Patient-Activated Reliever-Triggered Inhaled Corticosteroid), instructed to “take one puff of Inhaled Corticosteroids (ICS) for each puff of rescue inhaler” or “5 puffs of ICS after their nebulizer/machine treatment“), showed a decrease in asthma attacks by 15% compared to the Usual Care group. This was 13 fewer asthma attacks per 100 patients a year compared to Usual Care.
Also, the PARTICS group had better asthma control, better quality of life and missed fewer days of work/school and their usual activities compared to the Usual Care group.
Reducing the disproportionate burden of disease from asthma in Black and Latinx patients has been difficult. In collaboration with Patient Partner advisors, we demonstrated that PARTICS – (Patient-Activated Reliever-Triggered Inhaled Corticosteroid) added to underlying therapy in Black and Latinx adults with moderate-severe asthma:
•Was adopted after 1 in-person session
•Reduced asthma exacerbations
•Improved asthma control
•Improved quality of life
•Reduced days lost from work/school
•Reductions in severe exacerbations were equal or greater than relevant SMART trials
•Does not require changes in underlying controller therapy
•The total extra ICS use in PARTICS+UC was 1.1 refills/yr.
•Required less extra controller than reported with SMART
•Tested in populations using rescue nebulizers
•Does not challenge FDA restrictions
•Tested in a broad population without restrictions on asthma phenotypes