The New England Journal of Medicine
The PARTICS group (intervention) used 1 puff of beclomethasone 80mcg (QVAR) with each puff of rescue beta-agonist and 5 puffs of QVAR when they used nebulized beta-agonist.
Asthma exacerbations were significantly reduced, asthma control improved, and patients decreased their use of beta-agonists. The average yearly increase of controller medications (accounting for a reduction in maintenance controllers) was only 1.1 cannisters a year